IMPORTANT INFORMATION
THAT COULD SAVE YOUR AUSSIES LIFE!
AUSSIE DRUG TOXICITY - MDR1 GENE

It is well known that certain breeds have reactions to certain drugs. It was previously unknown why
some dogs were sensitive and some not. Advances in molecular biology has found the problem
to be due to a mutation in the multi-drug resistant gene (MDR1).  This gene encodes a protein,
P-glycoprotien, that is responsible for pumping many drugs and other toxins out of the brain. Dogs
with the mutant gene can not pump some drugs out of the brain as a normal dog would. The
result may be illness possibly requiring an extended hospital stay, or even death. You simply need
to use alternative drugs recommended by you vet that are safe for these breeds.

Infected breeds that have been positively diagnosed include Collies, Shetland Sheepdogs,
Australian Shepherds (all three sizes), Old English Sheepdogs, German Shepherds, Long-Haired
Whippets & Silken Wind hounds. As the testing becomes more precise, there may be more
breeds and drugs added to the list.

Not every dog within a breed has the mutant gene. A test has been developed at Washington State
University to screen for the presence of the mutant gene. Click on the link at the bottom of this
page to find out how to have your dog tested and to learn more. Below is a list of drugs that have
been documented, or are strongly suspected to cause problems in dogs with MDR1 Gene
Mutation:
STANDARD, MINIATURE OR TOY SIZED AUSTRALIAN SHEPHERDS HAVE DOCUMENTED
SENSITIVITY TO CERTAIN DRUGS.

PLEASE PRINT THIS LIST FOR YOURSELF AND YOUR VET AS A SAFETY PRECAUTION.

SICKNESS OR EVEN DEATH CAN EASILY BE AVOIDED BY STAYING AWAY FROM THE
FOLLOWING DRUGS OR HAVING YOUR DOG TESTED BEFORE USING THEM!
PROBLEM  DRUGS
  • IVERMECTIN          (antiparasitic agent)
  • LOPERAMIDE        (imodium, over the counter human anti-diarrhea agent)
  • DOXORUBICIN      (anti-cancer agent)
  • VINCRISTINE         (anti-cancer agent)
  • VINBLASTINE         (anti-cancer agent)
  • CYCLOSPORIN     (immunosuppressive agent)
  • DIGOXIN                  (heart drug)
  • ACEPROMAZINE    (tranquilizer)
  • BUTAPHONAL         (pain control)
THE FOLLOWING IS A LIST OF POTENTIAL PROBLEM DRUGS
  • ONDANSETRON
  • DOMPERIDONE
  • PACLITAXEL
  • MITOXANTRONE
  • ETOPOSIDE
  • RIFAMPICIN
  • QUINIDINE
  • MORPHINE
Please Click on the LINK below to learn more about the MDR1 GENE

Please share this information with anyone that you know that has any of the breeds that are effected
CLICK HERE TO LEARN MORE ABOUT MDR1 GENE
Lone P i ne Aussies